Quiet Tone Official Website › Side Effects
Side EffectsQuiet Tone Side Effects: What Each Ingredient Can Do
Quiet Tone's possible side effects come from the safety record of its individual ingredients.
Five ingredients have a known safety signal. St John's wort interacts with hormonal contraception and transplant drugs, and 5-HTP with serotonergic antidepressants, so check with a doctor if you take these.
To check your fit, see who it is for.
What is documented, what is predicted by the composition, and what is simply not known.
What is actually known about Quiet Tone side effects?
No trial of this formula exists, so this page works from the ingredient literature.
The precise answer is that no adverse-event record exists for this finished formula, because no trial of it has been run and no post-market surveillance data is published. That is true of nearly every multi-ingredient supplement on sale and it is the starting point rather than a scandal.
What does exist, and what this page is built from, is the safety literature on the individual ingredients. Twenty-four actives, several of them with decades of human data behind them, and four with a documented signal worth naming. Reading that literature against the amounts on this panel is the closest thing to an honest answer available.
- The amount. Most published adverse signals sit at doses far above a blend this size.
- The medicines you already take. Two ingredients here interact with named drug classes.
- The form. Oxide and carbonate salts are gentle on the stomach precisely because little is absorbed.
- Your own history. The label asks anyone with a known medical condition to speak to a physician first, and that instruction is quoted in full below.
Everything that follows is organised by ingredient rather than by symptom, because a symptom list detached from a cause is unusable.
What are the most likely Quiet Tone effects in the first week?
Four things the composition predicts, three of them cosmetic.
Three, and two of them are cosmetic. None is a reason to stop, and knowing about them in advance prevents a perfectly ordinary capsule being mistaken for a problem.
Bright yellow urine
Riboflavin at 462% of a Daily Value. The pigment is excreted unchanged and the colour appears within hours of the first capsule. It is harmless, it is the commonest thing anyone notices on a B-complex, and it stops when the capsule stops.
A warm flush
Niacin at 14 mg NE is well below the range where flushing usually appears, and the label uses nicotinic acid rather than the non-flushing amide. A brief warmth in the face or chest twenty minutes after a capsule is possible and self-limiting.
Mild stomach upset on an empty stomach
The label asks for the capsule twenty to thirty minutes before a meal with eight ounces of water. Anyone who finds that uncomfortable can take it closer to the meal; the instruction is a preference on the artwork rather than a requirement.
Daytime settling
Fifteen of the eighteen blend members are calm-and-sleep plants. Feeling settled rather than sharp is the formula doing what its composition suggests, and moving the capsule to the evening is the obvious response.
None of those four appears in a published adverse-event report for this product, because no such reporting exists. They are what the composition predicts, set out so that a first-week experience can be recognised rather than guessed at.
Which Quiet Tone ingredients carry a documented safety signal?
Five ingredients with a real published record, and the dose that record came from.
Five, and each one is named here with its mechanism, its published record and the amount at which that record was generated. The amount column is the one that puts the rest in proportion.
| Ingredient | The documented signal | Where it was recorded | On this panel |
|---|---|---|---|
| Ashwagandha | Rare liver injury, reversible in the reported cases | The DILIN case series and a series from India, with NCCIH carrying the summary | In the blend, unquantified |
| Chinese skullcap | Liver injury, mostly in multi-ingredient products | The published case literature | In the blend, unquantified |
| Vitamin B6 | Sensory neuropathy at sustained high intakes | The toxic-threshold work and a case from daily multivitamin use | 4 mg, far below that range |
| Biotin | Immunoassay interference, including troponin | The standing review and a study of time-critical analytes | 150 mcg, enough to matter at a blood draw |
| St John’s wort | Enzyme induction, photosensitivity | CYP3A4 induction data and NCCIH | In the blend, unquantified |
A signal recorded at a therapeutic single-ingredient dose does not automatically apply to a share of a 415.5 mg blend. It is listed because the ingredient is on the label.
Two general observations belong with that table. The first is that unquantified is genuinely double-edged here: it means the amounts are almost certainly well below the doses at which these signals were recorded, and it also means nobody can confirm that. The second is that the herbal sedative literature and work on botanical product quality both note that multi-ingredient products are over-represented in liver-injury case series, which is a reason to know what is in a bottle rather than a reason to avoid the category.
Which medicines interact with Quiet Tone?
Four specific combinations, each with the published record behind it.
Two ingredients, four drug classes, and this is the most important section on the page for anyone holding a prescription.
St John’s wort and hormonal contraception
Breakthrough bleeding and reduced contraceptive levels are reported, and a systematic review gathers the case record in one place. The mechanism is CYP3A4 induction, which speeds the clearance of the hormone. Anyone relying on hormonal contraception should treat this as a reason to talk to their prescriber before the first capsule rather than as a general caution.
St John’s wort and transplant immunosuppressants
Ciclosporin levels fall far enough to threaten a graft. This is the most serious interaction on the label and transplant teams ask about the ingredient by name. The wider pharmacokinetic data covers the other substrates affected, which include several cardiac and antiviral medicines.
5-HTP and serotonergic antidepressants
5-HTP is a direct serotonin precursor. Serotonin syndrome has been reported where it is combined with serotonergic medicines, and the 5-HTP review sets out the background. The controlled trial used 100 mg a day; the amount here is a share of one blend row and is unquantified.
Valerian, hops and anything sedating
Additive sedation is the expected direction with alcohol, prescription sedatives or antihistamines. NCCIH carries the plain summary. Passion flower has been studied as a pre-operative sedative, which is a useful indication of the direction of travel.
One further note that is not a drug interaction at all: the wider herb-drug enzyme literature covers several other botanicals on this panel at the level of theory rather than of reported cases. Naming the four above precisely is more useful than a general warning about herbs, which tells nobody anything they can act on.
When should someone stop taking Quiet Tone?
Five reasons to stop, most of them from the label itself.
A short list, and it is short on purpose. Most of it is the label’s own instruction rather than this desk’s addition.
- Any yellowing of skin or eyes, dark urine that is not the riboflavin colour, or persistent right-sided abdominal pain — the liver signal named above
- A rash that appears in sunlight, which is the St John’s wort photosensitivity
- Agitation, sweating, tremor or confusion starting after a new serotonergic medicine is added
- Any new symptom that began with the capsule and settles when it stops
- Before any scheduled surgery, because of the sedative rows and the standard advice to pause supplements
Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Keep out of reach of children. Do not use if safety seal is damaged or missing.
Beyond that list, one practical matter: mention the biotin row before a blood test. It is not a safety issue with the capsule, it is a laboratory one, and it is the single most actionable sentence on this page for anyone with a cardiac or thyroid test scheduled.
Adverse events with any dietary supplement can be reported to the FDA’s MedWatch programme. Nothing on this site is a substitute for the judgement of whoever issued your prescriptions, and the 180-day refund window means stopping carries no financial penalty inside that period.
Quiet Tone safety questions
Does Quiet Tone have side effects?
No adverse-event record exists for this finished formula, because no trial of it has been published. The composition predicts bright yellow urine from the riboflavin, possible mild warmth from the niacin, and daytime settling from a blend that is fifteen parts calm-and-sleep plants out of eighteen.
Is Quiet Tone safe with blood pressure medication?
The specific documented interactions on this panel are St John’s wort with hormonal contraception and with transplant immunosuppressants, and 5-HTP with serotonergic antidepressants. St John’s wort induces CYP3A4, which affects several cardiac medicines, so anyone on one should raise the bottle with their prescriber.
Can Quiet Tone affect a blood test?
Yes, and this is worth knowing. Biotin at 150 mcg interferes with the streptavidin chemistry used in many immunoassays. Time-critical analytes including troponin are affected. Mention it at the blood draw.
Does Quiet Tone cause drowsiness?
The blend leans sedative, so feeling settled is consistent with the composition. The label sets no time of day, so the capsule can move to the evening. Additive sedation with alcohol or prescription sedatives is the expected direction.
Is the ashwagandha in Quiet Tone a liver risk?
Rare, reversible liver injury has been reported with ashwagandha at single-ingredient therapeutic doses, in a DILIN case series and a series from India. The amount inside this blend is unquantified but is a share of 415.5 mg split eighteen ways, far below those doses.
Can Quiet Tone be taken long term?
The label sets no maximum duration, no cycle and no break. The published safety signals on this panel come from single-ingredient doses well above what one blend row can hold, and the nine printed nutrients are all well below their tolerable upper intakes.
Sources for the Quiet Tone safety record
Every case series, review and interaction study named above, grouped by the ingredient it belongs to.
- Björnsson HK, Björnsson ES, Avula B, et al. Ashwagandha-induced liver injury: a case series from Iceland and the US Drug-Induced Liver Injury Network. Liver Int. 2020;40(4):825-829. PMID 31991029. https://pubmed.ncbi.nlm.nih.gov/31991029/
- Philips CA, Valsan A, Theruvath AH, et al. Ashwagandha-induced liver injury — a case series from India and literature review. Hepatol Commun. 2023;7(10):e0270. PMID 37756041. https://pubmed.ncbi.nlm.nih.gov/37756041/
- National Center for Complementary and Integrative Health. Ashwagandha. National Institutes of Health. Read 19 September 2026. https://www.nccih.nih.gov/health/ashwagandha
- Fu L, Ji L, Yan X, et al. ABCB1 rs2032582 as a potential biomarker for predicting Scutellaria baicalensis Georgi-drug induced liver injury in humans. J Ethnopharmacol. 2026;374(Pt 1):122329. PMID 42665171. https://pubmed.ncbi.nlm.nih.gov/42665171/
- Katan MB. [How much vitamin B6 is toxic?] Ned Tijdschr Geneeskd. 2005;149(46):2545-6. PMID 16320662. https://pubmed.ncbi.nlm.nih.gov/16320662/
- Paluszny A, Qiu S. Vitamin B6 toxicity secondary to daily multivitamin use: a case report. Cureus. 2023;15(11):e48792. PMID 38098895. https://pubmed.ncbi.nlm.nih.gov/38098895/
- Dasgupta A. Immunoassay design and biotin interference. Adv Clin Chem. 2022;109:165-183. PMID 35953126. https://pubmed.ncbi.nlm.nih.gov/35953126/
- Mrosewski I, Urbank M, Stauch T, Switkowski R. Interference from high-dose biotin intake in immunoassays for potentially time-critical analytes by Roche. Arch Pathol Lab Med. 2020;144(9):1108-1117. PMID 31944861. https://pubmed.ncbi.nlm.nih.gov/31944861/
- Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA. 2003;290(11):1500-4. PMID 13129991. https://pubmed.ncbi.nlm.nih.gov/13129991/
- Murphy PA, Kern SE, Stanczyk FZ, Westhoff CL. Interaction of St. John's wort with oral contraceptives: effects on the pharmacokinetics of norethindrone and ethinyl estradiol, ovarian activity and breakthrough bleeding. Contraception. 2005;71(6):402-8. PMID 15914127. https://pubmed.ncbi.nlm.nih.gov/15914127/
- Berry-Bibee EN, Kim MJ, Tepper NK, Riley HE, Curtis KM. Co-administration of St. John's wort and hormonal contraceptives: a systematic review. Contraception. 2016;94(6):668-677. PMID 27444983. https://pubmed.ncbi.nlm.nih.gov/27444983/
- Ernst E. St John's wort supplements endanger the success of organ transplantation. Arch Surg. 2002;137(3):316-9. PMID 11888457. https://pubmed.ncbi.nlm.nih.gov/11888457/
- Zhou S, Chan E, Pan SQ, Huang M, Lee EJ. Pharmacokinetic interactions of drugs with St John's wort. J Psychopharmacol. 2004;18(2):262-76. PMID 15260917. https://pubmed.ncbi.nlm.nih.gov/15260917/
- National Center for Complementary and Integrative Health. St. John's Wort. National Institutes of Health. Read 19 September 2026. https://www.nccih.nih.gov/health/st-johns-wort
- de Dios I, Rialp G, Franco S, Romero M, Ortega M, Nieto Y. The role of chronic nutritional supplements consumption in a fulminant serotonin syndrome due to citalopram intoxication. Med Intensiva (Engl Ed). 2019;43(9):582-583. PMID 29317102. https://pubmed.ncbi.nlm.nih.gov/29317102/
- Turner EH, Loftis JM, Blackwell AD. Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan. Pharmacol Ther. 2006;109(3):325-38. PMID 16023217. https://pubmed.ncbi.nlm.nih.gov/16023217/
- Li S, Sutanto CN, Xia X, Kim JE. The impact of 5-hydroxytryptophan supplementation on cognitive function and mood in Singapore older adults: a randomized controlled trial. Nutrients. 2025;17(17):2773. The trial dose was 100 mg a day for twelve weeks. PMID 40944161. https://pubmed.ncbi.nlm.nih.gov/40944161/
- Căuș MN, Lupoae M, Chițescu CL. Efficacy and safety of herbal supplements with anxiolytic, antidepressant, and sedative action: a review of clinical data and toxicological risks. Pharmaceuticals (Basel). 2026;19(3):337. PMID 41901246. https://pubmed.ncbi.nlm.nih.gov/41901246/
- National Center for Complementary and Integrative Health. Valerian. National Institutes of Health. Read 19 September 2026. https://www.nccih.nih.gov/health/valerian
- Lima Neto TJ, Ribeiro NP, Souza MB, et al. Effects of Passiflora incarnata on salivary biomarkers and anxiety in patients undergoing third molar extraction surgery. Sci Rep. 2025;15(1):43616. Thirty patients; salivary cortisol fell, subjective anxiety did not. PMID 41381570. https://pubmed.ncbi.nlm.nih.gov/41381570/
- Hsieh YH, Huang ST. Interactions between cytochrome P450 enzymes and traditional Chinese herbs: a comprehensive review. J Chin Med Assoc. 2026;89(8):578-592. PMID 42421515. https://pubmed.ncbi.nlm.nih.gov/42421515/
- Roe AL, Krzykwa J, Calderón AI, et al. Developing a screening strategy to identify hepatotoxicity and drug interaction potential of botanicals. J Diet Suppl. 2025;22(1):162-192. PMID 39450425. https://pubmed.ncbi.nlm.nih.gov/39450425/
Order Quiet Tone with the safety picture in view
One capsule a day, a vegetarian shell, the label’s own caution printed in full on this page, and 180 days from purchase to change your mind.
Two bottles $158 · six bottles $294 · 180-day money-back guarantee
Order Quiet Tone On The Official WebsiteOne capsule a day · 30 per bottle · lot QUI-26/QU-5380
